Network-based hub biomarker discovery for glaucoma.

ABSTRACT:

Objective

Glaucoma is an optic neuropathy and the leading cause of irreversible blindness worldwide. However, the early detection of glaucoma remains challenging, as chronic forms of glaucoma remain largely asymptomatic until considerable irreversible visual field deficits have ensued. Thus, biomarkers that facilitate early diagnosis and treatment for glaucoma patients with a high risk of progression are pressing.

Methods and analysis

Human disease-biomarker interactions network and human disease-target-drug interactions network were first constructed based on multiomics data. The greedy search algorithm was used to search for the hub biomarkers and drug targets for glaucoma. Genome-wide association studies and epidemiological data from the UK Biobank were used to verify our

SUBMITTER: Li M 

PROVIDER: S-EPMC11580298 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature