In vitro detection of cancer cells using a novel fluorescent choline derivative.

ABSTRACT:

Introduction

The treatment of preinvasive lesions is more effective than treating invasive disease, hence detecting cancer at its early stages is crucial. However, currently, available screening methods show various limitations in terms of sensitivity, specificity, and practicality, thus novel markers complementing traditional cyto/histopathological assessments are needed. Alteration in choline metabolism is a hallmark of many malignancies, including cervical and breast cancers. Choline radiotracers are widely used for imaging purposes, even though many risks are associated with their radioactivity. Therefore, this work aimed to synthesise and characterise a non-radioactive choline tracer based on a fluorinated acridine scaffold (CFA) for the in vitro detection of cervical and brea

SUBMITTER: Caprifico AE 

PROVIDER: S-EPMC11580358 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature