Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice.

ABSTRACT:

Background

Dietary restriction (DR) has multiple beneficial effects on health and longevity and can also improve the efficacy of certain therapies. Diets used to instigate DR are diverse and the corresponding response is not uniformly measured. We compared the systemic and liver-specific transcriptional response to intermittent fasting (IF) and commercially available fasting-mimicking diet (FMD) after short- and long-term use in C57BL/6 J mice.

Results

We show that neither DR regimen causes observable adverse effects in mice. The weight loss was limited to 20% and was quickly compensated during refeeding days. The slightly higher weight loss upon FMD versus IF correlated with stronger fasting response assessed by lower glucose levels and higher ketone body, free fatty acids

SUBMITTER: Michenthaler H 

PROVIDER: S-EPMC11580389 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature