Unraveling the role of cAMP signaling in <i>Giardia</i>: insights into PKA-mediated regulation of encystation and subcellular interactions.

ABSTRACT: cAMP plays an important role as a second messenger in the stage transition of various protozoan parasites. This signaling pathway relies on multiple effectors, such as protein kinase A (PKA), exchange protein activated by cAMP, and cAMP-response element binding protein transcription factors, to initiate signal transduction in humans. The Giardia genome only contains two adenylate cyclases (ACs), a single phosphodiesterase (PDE) and a single known PKA effector, and the specific functions of these components are not fully understood. In our previous research, we demonstrated the important role of AC2-dependent cAMP signaling in promoting the encystation program. Using the NanoBit technology, we emphasized the significance of AC2-dependent cAMP biosynthesis in regulating the dissociati

SUBMITTER: Shih H-W 

PROVIDER: S-EPMC11580427 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature