<i>Chlamydia trachomatis</i> Inc Ct226 is vital for FLI1 and LRRF1 recruitment to the chlamydial inclusion.

ABSTRACT: The obligate intracellular pathogen, Chlamydia trachomatis, establishes an intracellular niche within a host membrane-derived vacuole called the chlamydial inclusion. From within this inclusion, C. trachomatis orchestrates numerous host-pathogen interactions, in part, by utilizing a family of type III secreted effectors, termed inclusion membrane proteins (Incs). Incs are embedded within the inclusion membrane, and some function to recruit host proteins to the inclusion. Two such recruited host proteins are leucine rich repeat Flightless-1 interacting protein 1 (LRRF1/LRRFIP1) and its binding partner Flightless 1 (FLI1/FLII). Previously, LRRF1 has been shown to interact with Inc protein Ct226/CTL0478. This is the first study to examin

SUBMITTER: Sturd NA 

PROVIDER: S-EPMC11580450 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature