Adaptation to zinc restriction in <i>Streptococcus agalactiae</i>: role of the ribosomal protein and zinc-importers regulated by AdcR.

ABSTRACT: Zinc (Zn) is an essential cofactor for numerous bacterial proteins and altering Zn availability is an important component of host innate immunity. During infection, adaptation to both Zn deprivation and excess is critical for pathogenic bacteria development. To understand the adaptive responses to Zn availability of Streptococcus agalactiae, a pathogen causing invasive infections of neonates, global transcriptional profiling was conducted. Results highlight that in response to Zn limitation, genes belonging to the AdcR regulon, the master regulator of Zn homeostasis in streptococci, were overexpressed. Through a combination of in silico analysis and experimental validation, new AdcR-regulated targets were identified. Among them, we identified a duplicated ribosomal protein, R

SUBMITTER: Melet M 

PROVIDER: S-EPMC11580457 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature