The vibriophage-encoded inhibitor OrbA abrogates BREX-mediated defense through the ATPase BrxC.

ABSTRACT: Bacteria and phages are locked in a co-evolutionary arms race where each entity evolves mechanisms to restrict the proliferation of the other. Phage-encoded defense inhibitors have proven powerful tools to interrogate how defense systems function. A relatively common defense system is BREX (bacteriophage exclusion); however, how BREX functions to restrict phage infection remains poorly understood. A BREX system encoded by the sulfamethoxazole and trimethoprim (SXT) integrative and conjugative element, VchInd5, was recently identified in Vibrio cholerae, the causative agent of the diarrheal disease cholera. The lytic phage ICP1 (International Centre for Diarrhoeal Disease Research, Bangladesh cholera phage 1) that co-circulates

SUBMITTER: Oshiro RT 

PROVIDER: S-EPMC11580459 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature