<i>Candida glabrata</i> maintains two <i>HAP1</i> ohnologs, <i>HAP1A</i> and <i>HAP1B</i>, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditions.

ABSTRACT: Candida glabrata exhibits innate resistance to azole antifungal drugs but also has the propensity to rapidly develop clinical drug resistance. Azole drugs, which target Erg11, is one of the major classes of antifungals used to treat Candida infections. Despite their widespread use, the mechanism controlling azole-induced ERG gene expression and drug resistance in C. glabrata has primarily revolved around Upc2 and/or Pdr1. Phylogenetic and syntenic analyses revealed that C. glabrata, following a whole genome duplication event, maintained HAP1A and HAP1B, whereas Saccharomyces cerevisiae only retained the HAP1A ortholog, HAP1. In this study, we determined the function of two zinc cluster transcription factors, Hap1A and Ha

SUBMITTER: Saha D 

PROVIDER: S-EPMC11580460 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature