Lower prognostic nutritional index is associated with a greater decline in long-term kidney function in general population.

ABSTRACT:

Background

The prognostic nutritional index (PNI) is an integrated index of serum albumin and peripheral lymphocyte count, where low values may reflect poor nutritional status or inflammation. The long-term effect of PNI on renal function is not well known in the general population. Therefore, we investigated whether the PNI is related to renal function changes in the general population.

Methods

Data from participants who underwent a health check-up between 2002 and 2018 were retrospectively examined. PNI was computed by 10×serum albumin (g/dL) + 0.005×total lymphocyte count (per mm3). The primary exposure was PNI, divided into quintiles. The primary outcome was a 25% decline in eGFR from baseline over a 5-year follow-up period.

Results

This study included 15,437 part

SUBMITTER: Park IH 

PROVIDER: S-EPMC11580526 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature