Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort.

ABSTRACT:

Background

Zearalenone (ZEN), a secondary metabolite of Fusarium fungi, is one of the most common mycotoxins in global food supplies such as cereal grains and processed food. ZEN and its metabolites are commonly referred to as mycoestrogens, due to their ability to directly bind nuclear estrogen receptors α (ER-α) and β (ER-β). Zeranol, a synthetic mycoestrogen, is administered to U.S. cattle as a growth promoter. Despite widespread human exposure and ample evidence of adverse reproductive impacts in vitro and in vivo, there has been little epidemiological research on the health impacts of ZEN exposure during pregnancy. The objective of our study was to examine associations between ZEN and gestational weight gain (GWG).

Methods

Urine samples were collected in each trimester

SUBMITTER: Kinkade CW 

PROVIDER: S-EPMC11580541 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature