Metformin regulates cellulase production in Trichoderma reesei via calcium signaling and mitochondrial function.

ABSTRACT:

Background

Trichoderma reesei is renowned for its cellulase-producing ability and is used for biofuel production from lignocellulose. In plants and fungi, cellulase production is induced by cellulose and suppressed by glucose; however, whether metformin can enhance cellulase production and mitochondrial function in T. reesei remains unclear. Metformin reduces blood glucose levels by inhibiting hepatic gluconeogenesis; therefore, it is worth investigating whether metformin transmission modulates cellulase biosynthesis in T. reesei.

Results

Metformin increased cellulase production and the transcription of cellulase-related genes. It also enhanced the concentrations of Ca²⁺ in the cytosol and mitochondria and regulated the transcription levels of cellulase-related ge

SUBMITTER: Wang J 

PROVIDER: S-EPMC11580550 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature