High-throughput screening-based design of multifunctional natural polyphenol nano-vesicles to accelerate diabetic wound healing.

ABSTRACT: Oxidative stress is a major pathological factor that impedes the diabetic wound healing process. Procyanidins (PC) form nanoparticle-vesicles (PPNs) through hydrogen bonding and exhibit good drug delivery capability; however, their application in diabetic wounds is unsatisfactory. To meet the antioxidant needs for treating, high-throughput screening in the natural product library (NPL) under in vitro oxidative stress conditions was conducted to enhance the antioxidant activity of PPNs. HUVECs treated with tert-Butyl Hydroperoxide (TBHP) were established as screening model in vitro. Baicalein (BAI) was identified from over 600  products in the library as the most effective one to combat oxidative stress. Further study showed that PC and BAI may react in equal proportions to synthesize new v

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11580636 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature