Systematic review of Mendelian randomization studies on antihypertensive drugs.

ABSTRACT:

Background

We systematically reviewed Mendelian randomization (MR) studies and summarized evidence on the potential effects of different antihypertensive drugs on health.

Methods

We searched PubMed and Embase for MR studies evaluating the effects of antihypertensive drug classes on health outcomes until 22 May 2024. We extracted data on study characteristics and findings, assessed study quality, and compared the evidence with that from randomized controlled trials (RCTs).

Results

We identified 2643 studies in the search, of which 37 studies were included. These studies explored a wide range of health outcomes including cardiovascular diseases and their risk factors, psychiatric and neurodegenerative diseases, cancer, immune function and infection, and other outcomes.

SUBMITTER: Fan B 

PROVIDER: S-EPMC11580643 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature