Causal effect between breast cancer and ovarian cancer: a two-sample mendelian randomization study.

ABSTRACT:

Objectives

Improved breast cancer (BC) outcomes highlight the importance of secondary primary cancers (SPCs) on survivor prognosis. The objective of this study was to investigate the potential genetic association between primary BC and ovarian cancer (OC), laying the groundwork for the development of preventive strategies for SPC-OC following BC surgery.

Methods

This study aimed to assess the connection between BC and OC using a two sample Mendelian randomization (MR) approach, exclusively employing aggregate level data from publicly available genome wide association studies (GWASs). Finally, the Genetic Risk Scores (GRS) method was used for secondary analysis to verify the results robustness further.

Results

The IVW method revealed a genetic correlation between Overa

SUBMITTER: Qian C 

PROVIDER: S-EPMC11580648 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature