<i>β</i>-Defensin <i>versus</i> conventional markers of inflammation in periprosthetic joint infection: a retrospective study.

ABSTRACT:

Background

Diagnosing periprosthetic joint infection (PJI) remains a significant challenge for healthcare professionals. Commonly utilized inflammatory markers include erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and white blood cells (WBC). Human β-defensin 1 (β-defensin) is an antimicrobial peptide elevated in infection, yet its diagnostic value for PJI has not been explored. The purpose of this study was to evaluate the efficacy of synovial β-defensin as a diagnostic marker for PJI and to compare its performance with ESR, serum CRP, and WBC.

Methods

We conducted a single-center retrospective study from October 2022 to June 2023. A total of 105 joint fluid samples from revision patients at the Instituto Nacional de Rehabilitación Lui

SUBMITTER: Fernandez-Torres J 

PROVIDER: S-EPMC11580661 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature