Regulation of disease-associated microglia in the optic nerve by lipoxin B₄ and ocular hypertension.

ABSTRACT:

Background

The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B₄ produced by homeostatic astrocytes directly acts on RGCs to increase survival and function in ocular hypertension-induced neuropathy. RGC death in the retina and axonal degeneration in the optic nerve are driven by the complex interactions between microglia and macroglia. Whether LXB₄ neuroprotective actions include regulation of other cell types in the retina and/or optic nerve is an important knowledge gap.

Methods

Cellular targets and signaling of LXB₄ in the retina were defined by single-cell RNA sequencing. Retinal neurodegeneration was induced by injecting sili

SUBMITTER: Maurya S 

PROVIDER: S-EPMC11580672 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature