Contribution of IL-17C-mediated macrophage polarization to Type 17 inflammation in neutrophilic asthma.

ABSTRACT:

Background

IL-17C has been described in a variety of inflammatory diseases driven by neutrophils. However, the role of IL-17C in neutrophilic asthma has not been completely characterized.

Methods

The level of IL-17C in asthmatic patients and mice was assessed. Il-17c-deficient mice or mice treated with exogenous rmIL-17C were performed for OVA/CFA-induced asthmatic mice model. Pulmonary inflammation was evaluated by histological analysis, flow cytometry and cytokine analysis. Il-17re-overexpressed Raw264.7 were used in vitro to investigate the role of IL-17C in macrophage polarization.

Results

Here, we show IL-17C were increased in serum or plasma from asthmatic patients and OVA/CFA-induced asthma mice. In the OVA/CFA-induced model, exogenous rmIL-17C aggravated neutr

SUBMITTER: Wen Y 

PROVIDER: S-EPMC11580697 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature