Increased neutrophil extracellular traps caused by diet-induced obesity delay fracture healing.

ABSTRACT: Obesity, recognized as a risk factor for nonunion, detrimentally impacts bone health, with significant physical and economic repercussions for affected individuals. Nevertheless, the precise pathomechanisms by which obesity impairs fracture healing remain insufficiently understood. Multiple studies have identified neutrophil granulocytes as key players in the systemic immune response, being the predominant immune cells in early fracture hematomas. This study identified a previously unreported critical period for neutrophil infiltration into the callus. In vivo experiments demonstrated that diet-induced obesity (DIO) mice showed earlier neutrophil infiltration, along with increased formation of neutrophil extracellular traps (NETs), compared to control mice during the endochondral phase of

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11580727 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature