The combined treatment with ketogenic diet and metformin slows tumor growth in two mouse models of triple negative breast cancer.

ABSTRACT:

Background

Many tumors contain hypoxic microenvironments caused by inefficient tumor vascularization. Hypoxic tumors have been shown to resist conventional cancer therapies. Hypoxic cancer cells rely on glucose to meet their energetic and anabolic needs to fuel uncontrolled proliferation and metastasis. This glucose dependency is linked to a metabolic shift in response to hypoxic conditions.

Methods

To leverage the glucose dependency of hypoxic tumor cells, we assessed the effects of a mild reduction in systemic glucose by controlling both dietary carbohydrates with a ketogenic diet and endogenous glucose production by using metformin on two mouse models of triple-negative breast cancer (TNBC).

Results

Here, we showed that animals with TNBC treated with the combinatio

SUBMITTER: Schmidt K 

PROVIDER: S-EPMC11580796 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature