Human xenobiotic metabolism proteins have full-length and split homologs in the gut microbiome.

ABSTRACT: Xenobiotics, including pharmaceutical drugs, can be metabolized by both host and microbiota, in some cases by homologous enzymes. We conducted a systematic search for all human proteins with gut microbial homologs. Because gene fusion and fission can obscure homology detection, we built a pipeline to identify not only full-length homologs, but also cases where microbial homologs were split across multiple adjacent genes in the same neighborhood or operon ("split homologs"). We found that human proteins with full-length gut microbial homologs disproportionately participate in xenobiotic metabolism. While this included many different enzyme classes, short-chain and aldo-keto reductases were the most frequently detected, especially in prevalent gut microbes, while cytochrome P450 homologs wer

SUBMITTER: Rendina M 

PROVIDER: S-EPMC11580864 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature