Accurate Detection of Tandem Repeats from Error-Prone Sequences with EquiRep.

ABSTRACT: A tandem repeat is a sequence of nucleotides that occurs as multiple contiguous and near-identical copies positioned next to each other. These repeats play critical roles in genetic diversity, gene regulation, and are strongly linked to various neurological and developmental disorders. While several methods exist for detecting tandem repeats, they often exhibit low accuracy when the repeat unit length increases or the number of copies is low. Furthermore, methods capable of handling highly mutated sequences remain scarce, highlighting a significant opportunity for improvement. We introduce EquiRep, a tool for accurate detection of tandem repeats from erroneous sequences. EquiRep estimates the likelihood of positions originating from the same position in the unit by self-alignment followed

SUBMITTER: Song Z 

PROVIDER: S-EPMC11580891 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature