A cross-species analysis of neuroanatomical covariance sex difference in humans and mice.

ABSTRACT: Structural covariance in brain anatomy is thought to reflect inter-regional sharing of developmental influences - although this hypothesis has proved hard to causally test. Here, we use neuroimaging in humans and mice to study sex-differences in anatomical covariance - asking if regions that have developed shared sex differences in volume across species also show shared sex difference in volume covariance. This study design illuminates both the biology of sex-differences and theoretical models for anatomical covariance - benefitting from tests of inter-species convergence. We find that volumetric structural covariance is stronger in adult females compared to adult males for both wild-type mice and healthy human subjects: 98% of all comparisons with statistically significant covariance sex

SUBMITTER: Pham L 

PROVIDER: S-EPMC11580902 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature