Polymicrobial interactions between <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> promote biofilm formation and persistence in chronic wound infections.

ABSTRACT: Chronic, non-healing wounds are a leading cause of prolonged patient morbidity and mortality due to biofilm- associated, polymicrobial infections. Staphylococcus aureus and Pseudomonas aeruginosa are the most frequently co-isolated pathogens from chronic wound infections. Competitive interactions between these pathogens contribute to enhanced virulence, persistence, and antimicrobial tolerance. P. aeruginosa utilizes the extracellular proteases LasB, LasA, and AprA to degrade S. aureus surface structures, disrupt cellular physiology, and induce cell lysis, gaining a competitive advantage during co-infection. S. aureus evades P. aeruginosa by employing aggregation mechanisms to form biofilms. The cell wall protein SasG is implicated in S.

SUBMITTER: Keim K 

PROVIDER: S-EPMC11580920 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature