Type IV pili-associated secretion of a biofilm matrix protein from <i>Clostridium perfringens</i> that forms intermolecular isopeptide bonds.

ABSTRACT: Clostridium perfringens is a Gram-positive, anaerobic, spore-forming, bacterial pathogen of humans and animals. C. perfringens also produces type IV pili (T4P) and has two complete sets of T4P-associated genes, one of which has been shown to produce surface pili needed for cell adherence. One hypothesis about the second set of T4P genes is that they comprise a system analogous to the type II secretion systems (TTSS) found in Gram-negative bacteria, which is used to export folded proteins from the periplasm through the outer membrane to the extracellular environment. Gram-positive bacteria have a similar secretion barrier in the thick peptidoglycan (PG) layer, which blocks secretion of folded proteins >25 kD. To determine if the T4P-associated genes comprise a Gram-positive TT

SUBMITTER: Kivimaki SE 

PROVIDER: S-EPMC11580942 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature