Septins regulate heart contractility through modulation of cardiomyocyte store-operated calcium entry.

ABSTRACT: Highly regulated cardiomyocyte Ca ²⁺ fluxes drive heart contractions. Recent findings from multiple organisms demonstrate that the specific Ca ²⁺ transport mechanism known as store-operated Ca ²⁺ entry (SOCE) is essential in cardiomyocytes for proper heart function, and SOCE dysregulation results in cardiomyopathy. Mechanisms that regulate SOCE in cardiomyocytes are poorly understood. Here we tested the role of cytoskeletal septin proteins in cardiomyocyte SOCE regulation. Septins are essential SOCE modulators in other cell types, but septin functions in cardiomyocytes are nearly completely unexplored. We show using targeted genetics and intravital imaging of heart contractility in Drosophila that cardiomyocyte-specific depletion of septins 1, 2, and

SUBMITTER: Tripoli BA 

PROVIDER: S-EPMC11580947 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature