Paired and solitary ionocytes in the zebrafish olfactory epithelium.

ABSTRACT: The sense of smell is generated by electrical currents that are influenced by the concentration of ions in olfactory sensory neurons and mucus. In contrast to the extensive morphological and molecular characterization of sensory neurons, there has been little description of the cells that control ion concentrations in the zebrafish olfactory system. Here, we report the molecular and ultrastructural characterization of zebrafish olfactory ionocytes. Transcriptome analysis suggests that the zebrafish olfactory epithelium contains at least three different ionocyte types, which resemble Na⁺/K⁺-ATPase-rich (NaR), H⁺-ATPase-rich (HR), and Na⁺/Cl^- cotransporter (NCC) cells, responsible for calcium, pH, and chloride regulation, respectively, i

SUBMITTER: Peloggia J 

PROVIDER: S-EPMC11580993 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature