Encoding opposing valences through frequency-dependent transmitter switching in single peptidergic neurons.

ABSTRACT: Peptidergic neurons often co-express fast transmitters and neuropeptides in separate vesicles with distinct release properties. However, the release dynamics of each transmitter in various contexts have not been fully understood in behaving animals. Here, we demonstrate that calcitonin gene-related peptide (CGRP) neurons in the external lateral subdivision of the parabrachial nucleus (CGRP^PBel) encode opposing valence via differential release, rather than co-release, of glutamate and neuropeptides, according to firing rate. Glutamate is released preferentially at lower firing rates with minimal release at higher firing rates, whereas neuropeptides are released at higher firing rates, resulting in frequency-dependent switching of transmitters. Aversive stimuli evoke high frequenc

SUBMITTER: Kim DI 

PROVIDER: S-EPMC11581014 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature