Severe motor impairment is associated with lower contralesional brain age in chronic stroke.

ABSTRACT:

Background

Stroke leads to complex chronic structural and functional brain changes that specifically affect motor outcomes. The brain-predicted age difference (brain-PAD) has emerged as a sensitive biomarker. Our previous study showed higher global brain-PAD associated with poorer motor function post-stroke. However, the relationship between local stroke lesion load, regional brain age, and motor impairment remains unclear.

Methods

We studied 501 individuals with chronic unilateral stroke (>180 days post-stroke) from the ENIGMA Stroke Recovery Working Group dataset (34 cohorts). Structural T1-weighted MRI scans were used to estimate regional brain-PAD in 18 predefined functional subregions via a graph convolutional network algorithm. Lesion load for each region was calculate

SUBMITTER: Park G 

PROVIDER: S-EPMC11581069 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature