Positive and negative affect, related mental health traits, and cognitive performance: shared genetic architecture and potential causality.

ABSTRACT: Altered affect and cognitive dysfunction are transdiagnostic, burdensome, and pervasive features of many psychiatric conditions which remain poorly understood and have few efficacious treatments. Research on the genetic architecture of these phenotypes and causal relationships between them may provide insight into their aetiology and comorbidity. Using data from the Lifelines Cohort Study, we conducted genome-wide association studies (GWAS) on positive and negative affect and four cognitive domains (working memory, reaction time, visual learning and memory, executive function). Using publicly available large GWAS on related - albeit distinct-phenotypes (depression, anxiety, wellbeing, general cognitive ability [GCA]) we conducted genetic correlation and Mendelian randomization (MR) analyse

SUBMITTER: Slaney C 

PROVIDER: S-EPMC11581074 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature