Antidepressant use during pregnancy and birth outcomes: analysis of electronic health data from the UK, Norway, and Sweden.

ABSTRACT:

Objectives

To explore the association between antidepressant use during pregnancy and birth outcomes.

Design

Cohort study.

Setting

Electronic health record data.

Participants

2 528 916 singleton births from the UK's Clinical Practice Research Datalink (1996-2018), Norway's Medical Birth Registry (2009-2020), and Sweden's Medical Birth Register (2006-2020).

Main outcome measures

Stillbirth, neonatal death, pre- and post-term delivery, small and large for gestational age, and low Apgar score five minutes post-delivery.

Results

A total of 120 209 (4.8%) deliveries were exposed to maternal antidepressant use during pregnancy. Maternal antidepressant use during pregnancy was associated with increased odds of stillbirth (adjusted pooled OR (aOR) 1.16, 9

SUBMITTER: Martin FZ 

PROVIDER: S-EPMC11581090 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature