Seasonal influenza vaccines: Variability of immune responses to B lineage viruses.

ABSTRACT: Although influenza A viruses predominate globally, influenza B viruses are responsible for a significant and often underappreciated burden. Despite this, immunity to influenza B viruses remains understudied, and there is a perception that vaccine-mediated immune responses to influenza B strains are less robust than influenza A strains. This targeted literature review examines this concept using data from pivotal phase 3 immunogenicity studies on currently licensed seasonal influenza vaccines and explores several explanations for this phenomenon, including immune exposure history, assay limitations, virus-related properties inherent to B lineages, and strain mismatch. Overall, studies demonstrated vaccines induce variable and sometimes less robust immune responses to influenza B strains; ho

SUBMITTER: Miller MS 

PROVIDER: S-EPMC11581161 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature