Antinociceptive effect of Equisetum arvense extract on the stomatitis hamster model.

ABSTRACT: Recurrent aphthous stomatitis leads to ulcers that cause severe pain, which is a substantial burden on patients. Equisetum arvense extract (EA) is a crude drug that promotes wound healing of mucous membranes caused by perineal incision during childbirth and alleviates pain. Here, we elucidated the effects of EA on wound healing and pain in a stomatitis hamster model. After stomatitis induction, two different EA doses were continuously applied to the wound area through the intramucosal injection of acetic acid into the cheek pouch (stomatitis/100*EA group and stomatitis/EA group). The body weight and wound area were measured over time, and histological evaluation was performed after stomatitis induction. The wound area was harvested 10 h after stomatitis induction, and gene expression assoc

SUBMITTER: Shiba F 

PROVIDER: S-EPMC11581248 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature