Integrated global and unique metabolic characteristics to reveal the intervention effect of Yiyi decoction on acute pancreatitis.

ABSTRACT: Yiyi decoction is a Chinese herbal formula for the treatment of acute pancreatitis that has been used in clinical practice for decades. A previous study has suggested that resveratrol, emodin, rhein and their derivatives might be the potential pharmacodynamic components in Yiyi decoction, and researchers have proposed that resveratrol, emodin and rhein are candidate markers for quality control. The present study investigated the intervention effect of Yiyi decoction and its effective components on murine acute pancreatitis using metabolomic approach that integrated global and unique metabolic characteristics. First, serum metabolomics based on the platform of ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was performed to assess metabo

SUBMITTER: Gong G 

PROVIDER: S-EPMC11581250 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature