Factors associated with low health-related quality of life in persons with multiple sclerosis: A quantile-based segmentation approach.

ABSTRACT:

Background

Improving health-related quality of life (HRQoL) is an important disease management goal in persons with Multiple Sclerosis (PwMS). HRQoL decreases with increasing age and prolonged disease duration; other factors remain less understood.

Objective

To identify associations of multiple sclerosis (MS) disease characteristics and symptom burden with low HRQoL.

Methods

Using the Swiss MS Registry, we applied quantile regression adjusted for age and MS disease duration to determine 25th (low HRQoL) and 75th (high HRQoL) percentiles of the EuroQol-5-Dimension (EQ-5D) distribution for PwMS. We compared PwMS across HRQoL groups by analyzing differences in sociodemographics, symptom burden, MS risk factors, gait impairment, and the MS Severity Score (MSSS), all measu

SUBMITTER: Iaquinto S 

PROVIDER: S-EPMC11581332 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature