Screening for Helicobacter pylori to Prevent Gastric Cancer: A Pragmatic Randomized Clinical Trial.

ABSTRACT:

Importance

Effects of screening for Helicobacter pylori on gastric cancer incidence and mortality are unknown.

Objective

To evaluate the effects of an invitation to screen for H pylori on gastric cancer incidence and mortality.

Design, setting, and participants

A pragmatic randomized clinical trial of residents aged 50 to 69 years in Changhua County, Taiwan, eligible for biennial fecal immunochemical tests (FIT) for colon cancer screening. Participants were randomized to either an invitation for H pylori stool antigen (HPSA) + FIT assessment or FIT alone. The study was conducted between January 1, 2014, and September 27, 2018. Final follow-up occurred December 31, 2020.

Intervention

Invitation for testing for H pylori stool antigen.

Main outcomes and measure

SUBMITTER: Lee YC 

PROVIDER: S-EPMC11581485 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature