Regional Variation in Deescalated Therapy in Older Adults With Early-Stage Breast Cancer.

ABSTRACT:

Importance

Although trial data support the omission of axillary surgery and radiation therapy (RT) in women aged 70 years or older with T1N0 hormone receptor-positive (HR+) breast cancer, potential overtreatment in older adults with frailty persists.

Objective

To determine how much geospatial variation in locoregional therapy may be attributed to region vs patient factors.

Design, setting, and participants

This retrospective cross-sectional study included women aged 70 years or older who were diagnosed with HR+/ERBB2-negative (ERBB2-) breast cancer from January 1, 2013, to December 31, 2017. Data came from Surveillance, Epidemiology, and End Results-Medicare. Hierarchical multivariable modeling was used to evaluate the variance in deescalated care attributable to 4 do

SUBMITTER: Minami CA 

PROVIDER: S-EPMC11581488 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature