Pregabalin for Neuropathic Pain and Itch in Recessive Dystrophic Epidermolysis Bullosa: A Randomized Crossover Trial.

ABSTRACT:

Importance

Patients with recessive dystrophic epidermolysis bullosa (RDEB) experience neuropathic pain and itch. There is a lack of evidence on any treatment for these symptoms in patients with RDEB.

Objectives

To test the efficacy of pregabalin in the treatment of neuropathic pain and itch in patients with RDEB.

Design, setting, and participants

A randomized, double-blinded, crossover trial of oral pregabalin (50-300 mg/d) vs placebo was conducted at 2 sites, Toronto (Canada) and Santiago (Chile) from January 1, 2019, to December 31, 2020. Patients eligible to participate were diagnosed with RDEB, aged 8 to 40 years, not pregnant or lactating (if female), and had evidence of probable neuropathic pain and itching defined as distal thermal sensory loss (confirmed by th

SUBMITTER: Calvo M 

PROVIDER: S-EPMC11581501 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature