Combined Methylphenidate and Selective Serotonin Reuptake Inhibitors in Adults With Attention-Deficit/Hyperactivity Disorder.

ABSTRACT:

Importance

Depression is a common comorbidity of adult attention-deficit/hyperactivity disorder (ADHD), and the combination of methylphenidate and selective serotonin reuptake inhibitors (SSRIs) is a frequently prescribed treatment. However, there is limited clinical evidence on the safety of this medication combination in adults with ADHD.

Objective

To evaluate the safety of administering a combination of SSRI and methylphenidate in adults with ADHD and comorbid depression.

Design, setting, and participants

This cohort study obtained data from a nationwide claims database in South Korea from January 2016 to February 2021. Participants were adults aged 18 years or older with a diagnosis of ADHD and depressive disorder who were prescribed methylphenidate. Comparisons o

SUBMITTER: Lee DY 

PROVIDER: S-EPMC11581539 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature