Multisite Skin Biopsies vs Cerebrospinal Fluid for Prion Seeding Activity in the Diagnosis of Prion Diseases.

ABSTRACT:

Importance

Recent studies have revealed that autopsy skin samples from cadavers with prion diseases (PRDs) exhibited a positive prion seeding activity similar to cerebrospinal fluid (CSF). It is worthwhile to validate the findings with a large number of biopsy skin samples and compare the clinical value of prion seeding activity between skin biopsies and concurrent CSF specimens.

Objective

To compare the prion seeding activity of skin biopsies and CSF samples and to determine the effectiveness of combination of the skin biopsies from multiple sites and numerous dilutions on the diagnosis for various types of PRDs.

Design, setting, and participants

In the exploratory cohort, patients were enrolled from September 15, 2021, to December 15, 2023, and were followed up ever

SUBMITTER: Chen ZY 

PROVIDER: S-EPMC11581550 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature