Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring.

ABSTRACT:

Importance

The association of folate supplementation with congenital heart disease (CHD) prevention is controversial.

Objective

To examine the association of maternal serum folate levels at early to midpregnancy with CHD risk in offspring.

Design, setting, and participants

This case-control study recruited participants from one of China's largest cardiac referral centers between 2015 and 2018. CHD cases and non-CHD controls were matched according to maternal age at a ratio of 1:4. Data were analyzed from May to August 2023.

Exposures

Maternal serum levels of folate, vitamin B12, and homocysteine were measured around the gestational age of 16 weeks.

Main outcomes and measures

The primary outcome was CHD, which was confirmed using echocardiography. The ass

SUBMITTER: Qu Y 

PROVIDER: S-EPMC11581582 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature