Pharmacologic Treatments for Dementia and the Risk of Developing Age-Related Macular Degeneration.

ABSTRACT:

Importance

Age-related macular degeneration (AMD) is the leading cause of blindness among people aged 50 years or older worldwide. There is a need for new strategies for the prevention and treatment of AMD. There is some limited evidence to suggest the possibility of a protective association of dementia medications with the development of some types of AMD, but the evidence is weak.

Objective

To investigate whether the dementia medications memantine and donepezil are associated with the risk of developing AMD.

Design, setting, and participants

Three population-based cohort studies were performed using data from the Clinical Practice Research Datalink GOLD and Aurum databases from May 15, 2002, to June 21, 2022. Participants included individuals with dementia (vascular

SUBMITTER: Wang J 

PROVIDER: S-EPMC11581610 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature