High-Risk Medications in Persons Living With Dementia: A Randomized Clinical Trial.

ABSTRACT:

Importance

Individuals with Alzheimer disease (AD) and Alzheimer disease-related dementias (ADRD) may be at increased risk for adverse outcomes relating to inappropriate prescribing of certain high-risk medications, including antipsychotics, sedative-hypnotics, and strong anticholinergic agents.

Objective

To evaluate the effect of a patient/caregiver and prescriber-mailed educational intervention on potentially inappropriate prescribing to patients with AD or ADRD.

Design, setting, and participants

This prospective, open-label, pragmatic randomized clinical trial, embedded in 2 large national health plans, was conducted from April 2022 to June 2023. The trial included patients with AD or ADRD and use of any of 3 drug classes targeted for deprescribing (antipsychotics,

SUBMITTER: Singh S 

PROVIDER: S-EPMC11581620 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature