GLP1R Gene Expression and Kidney Disease Progression.

ABSTRACT:

Importance

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) may have nephroprotective properties beyond those related to weight loss and glycemic control.

Objective

To investigate the association of genetically proxied GLP-1RAs with kidney disease progression.

Design, setting, and participants

This genetic association study assembled a national retrospective cohort of veterans aged 18 years or older from the US Department of Veterans Affairs Million Veteran Program between January 10, 2011, and December 31, 2021. Data were analyzed from November 2023 to February 2024.

Exposures

Genetic risk score for systemic GLP1R gene expression that was calculated for each study participant based on genetic variants associated with GLP1R mRNA levels across all tissue sam

SUBMITTER: Triozzi JL 

PROVIDER: S-EPMC11581634 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature