Coronary Revascularization Guided With Fractional Flow Reserve or Instantaneous Wave-Free Ratio: A 5-Year Follow-Up of the DEFINE FLAIR Randomized Clinical Trial.

ABSTRACT:

Importance

The differences between the use of fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) in the long term are unknown.

Objective

To compare long-term outcomes of iFR- and FFR-based strategies to guide revascularization.

Design, setting, and participants

The DEFINE-FLAIR multicenter study randomized patients with coronary artery disease to use either iFR or FFR as a pressure index to guide revascularization. Patients from 5 continents with coronary artery disease and angiographically intermediate severity stenoses who underwent hemodynamic interrogation with pressure wires were included. These data were analyzed from March, 13, 2014, through April, 27, 2021.

Main outcome measures

Five-year major adverse cardiac events (MACE) (a composit

SUBMITTER: Escaned J 

PROVIDER: S-EPMC11581635 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature