Psychometric Properties and Meaningful Change Thresholds of the Vitiligo Area Scoring Index.

ABSTRACT:

Importance

Defining meaningful improvement using the Total Vitiligo Area Scoring Index (T-VASI) and the Facial VASI (F-VASI) aids interpretation of findings from clinical trials evaluating vitiligo treatments; however, clear and clinically meaningful thresholds have not yet been established.

Objective

To assess concept validity and measurement performance of the T-VASI and F-VASI in patients with nonsegmental vitiligo and to identify meaningful change thresholds.

Design, settings, and participants

This mixed-methods study consisted of a secondary analysis of a phase 2 multicenter double-blind dose-ranging randomized clinical trial and embedded qualitative interviews conducted at 35 sites in Canada, France, Japan, and the US. The secondary analysis included the trial's

SUBMITTER: Ezzedine K 

PROVIDER: S-EPMC11581646 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature