Low-Dose Naltrexone Use in Biopsy-Proven Lichen Planus of the Nails.

ABSTRACT:

Importance

Nail lichen planus has the potential to cause permanent destruction of the nail unit and remains challenging to treat. Studies suggest that low-dose naltrexone is a safe and potentially effective treatment for other dermatologic conditions, including lichen planopilaris.

Objective

To assess the effectiveness of low-dose naltrexone in treating nail lichen planus.

Design, setting, and participants

This case series evaluates 7 adult patients with biopsy-proven nail lichen planus who were treated with low-dose naltrexone (3 mg per day) at the University of Miami dermatologic clinics from November 2022 to December 2023. The data were analyzed in March 2024. Patients were treated for at least 2 months and had in-person follow-up evaluation while receiving treatme

SUBMITTER: Bray ER 

PROVIDER: S-EPMC11581650 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature