Eligible Infants Included in Neonatal Clinical Trials and Reasons for Noninclusion: A Systematic Review.

ABSTRACT:

Importance

Results of clinical trials can only represent included participants, and many neonatal trials fail due to insufficient participation. Infants not included in research may differ from those included in meaningful ways, biasing the sample and limiting the generalizability of findings.

Objective

To describe the proportion of eligible infants included in neonatal clinical trials and the reasons for noninclusion.

Evidence review

A systematic search of Cochrane CENTRAL was performed by retrieving articles meeting the following inclusion criteria: full-length, peer-reviewed articles describing clinical trial results in at least 20 human infants from US neonatal intensive care units, published in English, and added to Cochrane CENTRAL between 2017 and 2022. Retriev

SUBMITTER: Shaikh H 

PROVIDER: S-EPMC11581680 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature