Sexual Trauma, Polygenic Scores, and Mental Health Diagnoses and Outcomes.

ABSTRACT:

Importance

Leveraging real-world clinical biobanks to investigate the associations between genetic and environmental risk factors for mental illness may help direct clinical screening efforts and evaluate the portability of polygenic scores across environmental contexts.

Objective

To examine the associations between sexual trauma, polygenic liability to mental health outcomes, and clinical diagnoses of schizophrenia, bipolar disorder, and major depressive disorder in a clinical biobank setting.

Design, setting, and participants

This genetic association study was conducted using clinical and genotyping data from 96 002 participants across hospital-linked biobanks located at Vanderbilt University Medical Center (VUMC), Nashville, Tennessee (including 58 262 individuals

SUBMITTER: Lake AM 

PROVIDER: S-EPMC11581726 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature