Patterns of Brain Maturation in Autism and Their Molecular Associations.

ABSTRACT:

Importance

In the neurotypical brain, regions develop in coordinated patterns, providing a fundamental scaffold for brain function and behavior. Whether altered patterns contribute to clinical profiles in neurodevelopmental conditions, including autism, remains unclear.

Objectives

To examine if, in autism, brain regions develop differently in relation to each other and how these differences are associated with molecular/genomic mechanisms and symptomatology.

Design, setting, and participants

This study was an analysis of one the largest deep-phenotyped, case-control, longitudinal (2 assessments separated by approximately 12-24 months) structural magnetic resonance imaging and cognitive-behavioral autism datasets (EU-AIMS Longitudinal European Autism Project [LEAP]; st

SUBMITTER: Pretzsch CM 

PROVIDER: S-EPMC11581727 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature