Antipsychotic Drugs and Cognitive Function: A Systematic Review and Network Meta-Analysis.

ABSTRACT:

Importance

Cognitive deficits are a substantial part of the symptoms of schizophrenia spectrum disorders (SSDs) and contribute heavily to the burden of disease. Antipsychotic drugs are not cognitive enhancers, but due to their different receptor-binding profiles, they could differ in their effects on cognition. No previous network meta-analysis compared antipsychotics to placebo, which is important to determine whether use of these drugs is associated with cognitive performance in SSDs at all.

Objective

To determine the association of treatment with various antipsychotics and cognition in patients with SSDs.

Data sources

Cochrane Schizophrenia Trials Register through June 25, 2023.

Study selection

Randomized clinical trials examining the effects on cognition of

SUBMITTER: Feber L 

PROVIDER: S-EPMC11581732 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature